MTC Lawler Studio, until July 7ROLAND Schimmelpfennig’s The Golden Dragon explodes the common misconception that German theatre after Brecht is somehow «anti literary» or that it has discarded narrative. It is, if anything, an act of pure, concentrated storytelling.As actors emerge and unfold Andrew Bailey’s garish set, we find ourselves in an unnamed German city, in the kitchen of a busy Chinese restaurant. The performers don’t primarily «embody» the characters in a traditional sense.
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Mice with global or interneuron specific heterozygous deletion of Nav1.1 exhibit temperature induced and spontaneous seizures, mild ataxia, autism like behaviours and premature death8,9,10. Knock in mouse carrying a premature stop codon in domain III of the Nav1.1 channel also exhibit a decrement in spike amplitude during prolonged interneuron firing and increased sensitivity to temperature induced seizures11.Generation and characterization of valid animal models is critical to efforts to understand the pathophysiology of DS, and to aid in the identification of novel therapies. Although considerable attention has focused on modelling SCN1A mutations in mice, these animals have proven to be difficult to breed, and epilepsy phenotypes are strongly influenced by the background strain genetics.
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The new owners had recently purchased Cincinnati based Lens Crafters, the largest chain of eyeglass retailers in the world.